What is it and how does it work?
Diuretics are usually wrong and referred to as “water pills”. Effect is most important is to reduce the total body sodium or salt. Long-acting diuretic useful in the treatment of Hypertension. They are cheap and effective for up to 24 hours.
This drug works in the kidneys and cause major salt to remove. Also relax the arteries. The result is a decrease in blood pressure.
Thiazide or thiazide diuretics as such: (most commonly used for Hypertension)
Hydrochlorothiazide or Indapamide
Short-acting loop diuretics: furosemide on Lasix, Puresis.These drug should not be used for Hypertension due to their short duration of action unless there is co-existing with advanced kidney disease or heart failure.
Potassium-sparing diuretics: spironolactone (Aldactone, Spiractin) and amiloride. Amiloride is only avaialble in combination with hydrochlorothiazide, for example Amiloretic.
Combining thiazide diuretics and potassium: Amiloretic, Moduretic, Hexa-retic
Who benefits from diuretics?
All patients with Hypertension benefit from treatment with a thiazide or thiazide, integration primarily as Ace inhibitors or angiotensin receptor blockers (ARBs). Patients sensitive to salt (eg Africa, the elderly and obese patients) respond best to diuretics Stage I Hypertension. Potassium-sparing diuretics are useful Particualrly in patients with resistant Hypertension, but should be used with caution in patients with kidney disease. The combination of a diuretic such Amiloretic should be used with extreme caution, as malignant changes in sodium and potassium in the blood occur if used in full dose. Dosage should not exceed half a tablet every day.
Compelling indications for the use of diuretics such as drug anti-hypertensive:
Patients with isolated systolic Hypertension
How do diuretics:
Your doctor will choose the appropriate diuretic and dosage for you. It should be taken in the morning, as it causes increased urination, especially at first.
Examples could be: hydrochlorothiazide 12.5 to 25 mg, taken in the morning
By limiting salt diet, diuretic pressure-lowering effect is enhanced, and may reduce the required dosage.
Increase your intake of potassium-rich foods, such as diuretics can decrease potassium in the body. Eat lots of fruits and vegetables. High doses should be avoided and the combination with inbibitor Ace or ARB reduces the problems associated with potassium depletion.
Who should not take diuretics?
Gout – Attacks precipitated.
Possible Contraindications / with caution:
Dyslipidemia (abnormal blood cholesterol)
Safety in pregnancy and lactation is not established
Diabetes – use low doses.
Patients with impaired kidney or liver function. Diuretics are not effective in Thiazide impaired renal function and duiuretics circle given twice daily is preferred.
Tell your doctor if:
You have gout.
Do you have a sexual Dysfunction.
You have diabetes.
You have kidney or liver problems.
You are taking any other medicines, including self-medication.
Possible side effects
Potassium levels in the blood may drop. You can change the heart rhythm, increases the toxicity of digoxin or lithium, predisposing causes weakness and diabetes. In the modern treatment of Hypertension, potassium depletion is rarely used because of the low dose and combination with ACE inhibitors reduce the loss of potassium. Potassium-sparing diuretics may be used if necessary. But the combination remains as current amiloretic not use the full dose due to adverse events were fatal.
Cramp in the legs can be a common side effect. Some patients may feel thirsty, dizzy or sleepy.
Men may experience erectile problems diuretics, and uric acid can be precipitated.
It can be taken with other medicines? Possible interactions of drugs:
Non-steroidal anti-inflammatory drugs: the drugs to block the action of diuretics.
May enhance the adverse effects of digitalis and lithium.
If taken corticosteroids, can increase the loss of potassium from the body.
Alcohol and drugs can exacerbate postural hypotension. Diuretics can increase dehydration and hangover after drinking alcohol.